ARHGEF4 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: Rho guanine nucleotide exchange factor(GEF) 4
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 72 kDa
Uniprot: Q9NR80
Gene id: 50649
Background: Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Field of research: Neuroscience, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: ARHGEF4
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: Rho guanine nucleotide exchange factor(GEF) 4
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 72 kDa
Uniprot: Q9NR80
Gene id: 50649
Background: Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Field of research: Neuroscience, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: ARHGEF4
Purification: Immunogen affinity purified
Reactivity: Human, Mouse