AMACR antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: alpha-methylacyl-CoA racemase
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 42 kDa
Uniprot: Q9UHK6
Gene id:
Background: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB
BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Field of research: Stem Cells, Immunology, Metabolism, Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: AMACR
Purification: Immunogen affinity purified
Reactivity: Human, rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: alpha-methylacyl-CoA racemase
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 42 kDa
Uniprot: Q9UHK6
Gene id:
Background: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB
BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Field of research: Stem Cells, Immunology, Metabolism, Cancer
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200
Target: AMACR
Purification: Immunogen affinity purified
Reactivity: Human, rat