AKT3 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: v-akt murine thymoma viral oncogene homolog 3(protein kinase B, gamma)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 54 kDa
Uniprot: Q9Y243
Gene id: 10000
Background: AKT3 is one of 3 closely related serine
threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and
or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:200-1:2000; IHC: 1:20-1:200
Target: AKT3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Zebrafish
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: v-akt murine thymoma viral oncogene homolog 3(protein kinase B, gamma)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 54 kDa
Uniprot: Q9Y243
Gene id: 10000
Background: AKT3 is one of 3 closely related serine
threonine-protein kinases(AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and
or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:200-1:2000; IHC: 1:20-1:200
Target: AKT3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat, Zebrafish