ADAM17-Specific antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ADAM metallopeptidase domain 17
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 29 kDa
Uniprot: P78536
Gene id: 6868
Background: The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:200-1:2000; IHC: 1:20-1:200
Target: ADAM17
Purification: Immunogen affinity purified
Reactivity: Human
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ADAM metallopeptidase domain 17
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 29 kDa
Uniprot: P78536
Gene id: 6868
Background: The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:200-1:2000; IHC: 1:20-1:200
Target: ADAM17
Purification: Immunogen affinity purified
Reactivity: Human