ACTL6A antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: actin-like 6A
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 47 kDa
Uniprot: O96019
Gene id: 86
Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling(alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4
BRG1
BAF190A and for association of the SMARCA4
BRG1
BAF190A containing remodeling complex BAF with chromatin
nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem
progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem
progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A
BAF53A and PHF10
BAF45A, are exchanged for homologous alternative ACTL6B
BAF53B and DPF1
BAF45B or DPF3
BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal
proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Component of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Field of research: Cell Division and Proliferation, Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000
Target: ACTL6A
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: actin-like 6A
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 47 kDa
Uniprot: O96019
Gene id: 86
Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling(alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4
BRG1
BAF190A and for association of the SMARCA4
BRG1
BAF190A containing remodeling complex BAF with chromatin
nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem
progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem
progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A
BAF53A and PHF10
BAF45A, are exchanged for homologous alternative ACTL6B
BAF53B and DPF1
BAF45B or DPF3
BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal
proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Component of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Field of research: Cell Division and Proliferation, Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000
Target: ACTL6A
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat